王晓娟(副教授)

发布时间:2017-03-02发布人:魏孟吉浏览次数:5019

?姓名: 王晓娟

?职称: 教授/硕士生导师

?系属: 应用化学系

?最高学位:博士

?学科: 应用化学/化学工程/功能材料/生物化工

?所学专业:化学

?电子邮箱:xwang@upc.edu.cn

?联系电话:13780668032/0532-86981560

?地址邮编:山东省青岛市黄岛区长江西路66号威尼斯官方网站,266580

?个人主页:

 ◎学习与工作经历

1995, 山东大学化学系,学士

2004, 瑞士巴塞尔大学(Basel University),Department of Chemistry,博士

2005-2009, 英国剑桥大学(Cambridge University),Department of Chemical Engineering and Biotechnology,博士后

2009-2011, 英国高科技上市公司  Nanoco Technologies Ltd,研究科学家

2011-至今, 青岛急需高层次人才,威尼斯,副教授

 ◎研究方向

化学工程,应用化学,材料化学与工程,生物化工

 ◎承担科研项目

1. 海藻基碳纳米复合光催化剂用于土壤内多氯联苯类污染物降解处理的应用效果评价,青岛市民生科技计划,17-3-3-76-nsh2017-2019

2. 智能型短肽修饰荧光金纳米簇的构建及其标记细胞核仁与载运核酸片段的功能开发,山东省重点研发计划,GG2017092801262018-2020

3. 石墨烯量子点对分子伴侣介导蛋白质折叠过程的影响及作用机理,山东省自然基金面上项目,ZR2017MB0392017-2020

4. 细胞膜上G蛋白偶联受体聚集与分布的荧光闪烁碳点超分辨成像,2019-2022

5. 用于重大恶性肿瘤早期预警的等离子体纳米镀膜检测芯片关键技术,山东省重点研发计划项目,2015GSF1180132015-2017

6. 利用多肽修饰的无镉量子点作为荧光探针研究CXCR4在细胞膜上的运动,国家自然科学基金青年项目,211032302012-2014

7. 无镉量子点在发光二极管技术中的应用,中央高校基本科研业务费专项基金,11CX05001A2011-2013

 ◎代表论文

1.Ma, X., Wang, X., Chen, Q., He, H., Sun, Y., Liu, H., Wang, Y., Qu, J. & Huang, F. Glycosaminoglycan / gold nanocluster hybrid nanoparticles as a new sensing platform: Metastatic potential assessment of cancer cells. Carbohydr Polym2020, 230, 115654.

2.Wang, Y., Wang, X., Ma, X., Chen, Q., He, H., Nau, W. M. & Huang, F. Coassembly of Gold Nanoclusters with Nucleic Acids: Sensing, Bioimaging, and Gene Transfection. Part Part Syst Charact2019, 36, 1900281.

3.Wang, X., Liu, Z., Chen, Q., Wang, X. & Huang, F. Interactions between Graphene Materials and Proteins. Progress in Chemistry2019, 31, 236-244.

4.Wang, X., Chen, Q., Zhang, Z., He, H., Ma, X., Liu, Z., Ge, B. & Huang, F. Novel Enteromorpha Prolifera based carbon dots: Probing the radical scavenging of natural phenolic compounds. Colloids Surf, B2019, 174, 161-167.

5.Jiang, G., Li, X., Che, Y., Lv, Y., Liu, F., Wang, Y., Zhao, C. & Wang, X. Antibacterial and anticorrosive properties of CuZnO@RGO waterborne polyurethane coating in circulating cooling water. Environmental Science and Pollution Research2019, 26, 9027-9040.

6.Wang, S., Cui, B., Cai, Q., Bu, Y., Wang, X., Cao, M., Xia, Y. & He, H. Fabrication of highly luminescent SiO2–Au nanostructures and their application in detection of trace Hg2+. J Mater Sci2019, 54, 7517-7528.

7.Xia, Y., Tang, D., Wu, H., Wang, X., Cao, M., He, H. & Wang, S. Cell attachment/detachment behavior on poly(N-isopropylacrylamide)-based microgel films: the effect of microgel structure and swelling ratio. J Mater Sci2018, 53, 8795-8806.

8.Song, Y., Ge, B., Lao, J., Wang, Z., Yang, B., Wang, X., He, H., Li, J. & Huang, F. Regulation of the Oligomeric Status of CCR3 with Binding Ligands Revealed by Single-Molecule Fluorescence Imaging. Biochemistry (Mosc)2018, 57, 852-860.

9.Khan, N. U., He, H., Wang, X., Ge, B., Wang, Q., Liu, X., Lao, J., Wang, Y., Li, J., Wang, Z., Zhou, S. & Huang, F. A two-color fluorescence enhanced dot-blot assay for revealing co-operative expression of chemokine receptors in cells. Chem Commun2018, 54, 778-781.

10.Khan, N. U., Feng, Z., He, H., Wang, Q., Liu, X., Li, S., Shi, X., Wang, X., Ge, B. & Huang, F. A facile plasmonic silver needle for fluorescence-enhanced detection of tumor markers. Anal Chim Acta2018, 1040, 120-127.

11.Jacob, M. H., D'Souza, R. N., Schwarzlose, T., Wang, X., Huang, F., Haas, E. & Nau, W. M. Method-Unifying View of Loop-Formation Kinetics in Peptide and Protein Folding. J Phys Chem B2018, 122, 4445-4456.

12.He, H., Li, S., Shi, X., Wang, X., Liu, X., Wang, Q., Guo, A., Ge, B., Khan, N. U. & Huang, F. Quantitative Nanoscopy of Small Blinking Graphene Nanocarriers in Drug Delivery. Bioconjug Chem2018, 29, 3658-3666.

13.Chi, H., Xu, B., Liu, Z., Wei, J., Li, S., Ren, H., Xu, Y., Lu, X., Wang, X., Wang, X. & Huang, F. Combined thermodynamic and kinetic analysis of GroEL interacting with CXCR4 transmembrane peptides. Biochim Biophys Acta2018, 1862, 1576-1583.

14.  Wang, X.; Wang, Y.; He, H.; Ma, X.; Chen, Q.; Zhang, S.; Ge, B.; Wang, S.; Nau, W. M.; Huang, F., Deep-Red Fluorescent Gold Nanoclusters for Nucleoli Staining: Real-Time Monitoring of the Nucleolar Dynamics in Reverse Transformation of Malignant Cells. ACS Appl. Mater. Interfaces 2017, 9 (21), 17799-17806.

  1. Xia, Y.; Tang, Y.; Wu, H.; Zhang, J.; Li, Z.; Pan, F.; Wang, S.; Wang, X.; Xu, H.; Lu, J. R., Fabrication of Patterned Thermoresponsive Microgel Strips on Cell-Adherent Background and Their Application for Cell Sheet Recovery. ACS Appl. Mater. Interfaces 2017,9 (2), 1255-1262.

16.Qu, J.-B.; Xu, Y.-L.; Liu, Y.; Wang, Y.; Sui, Y.; Liu, J.-G.; Wang, X., Inherently Fluorescent Polystyrene Microspheres for Coating, Sensing and Cellular Imaging. Colloids Surf., B 2017,152, 475-481.

17.Lao, J.; He, H.; Wang, X.; Wang, Z.; Song, Y.; Yang, B.; Ullahkhan, N.; Ge, B.; Huang, F., Single-Molecule Imaging Demonstrates Ligand Regulation of the Oligomeric Status of CXCR4 in Living Cells. J. Phys. Chem. B 2017,121 (7), 1466-1474.

18.He, H.; Liu, X.; Li, S.; Wang, X.; Wang, Q.; Li, J.; Wang, J.; Ren, H.; Ge, B.; Wang, S.; Zhang, X.; Huang, F., High-Density Super-Resolution Localization Imaging with Blinking Carbon Dots. Anal. Chem. 2017,89 (21), 11831-11838.

19.Wang, X.; Wang, Y.; He, H.; Chen, X.; Sun, X.; Sun, Y.; Zhou, G.; Xu, H.; Huang, F., Steering Graphene Quantum Dots in Living Cells: Lighting up the Nucleolus. J. Mater. Chem. B 2016,4 (4), 779-784.

20.Wang, X.; He, H.; Wang, Y.; Wang, J.; Sun, X.; Xu, H.; Nau, W. M.; Zhang, X.; Huang, F., Active Tumor-Targeting Luminescent Gold Clusters with Efficient Urinary Excretion. Chem. Commun. 2016,52 (59), 9232-9235.

21.He, H.; Wang, Z.; Cheng, T.; Liu, X.; Wang, X.; Wang, J.; Ren, H.; Sun, Y.; Song, Y.; Yang, J.; Xia, Y.; Wang, S.; Zhang, X.; Huang, F., Visible and near-Infrared Dual-Emission Carbogenic Small Molecular Complex with High Rna Selectivity and Renal Clearance for Nucleolus and Tumor Imaging. ACS Appl. Mater. Interfaces 2016,8 (42), 28529-28537.

22.He, H.; Wang, X.; Cheng, T.; Xia, Y.; Lao, J.; Ge, B.; Ren, H.; Khan, N. U.; Huang, F., An Ultra-High Fluorescence Enhancement and High Throughput Assay for Revealing Expression and Internalization of Chemokine Receptor Cxcr4. Chem.--Eur. J. 2016,22 (17), 5863-5867.

23.Yue, T.; Wang, X.; Zhang, X.; Huang, F., Molecular Modeling of Interaction between Lipid Monolayer and Graphene Nanosheets: Implications for Pulmonary Nanotoxicity and Pulmonary Drug Delivery. RSC Adv. 2015,5 (38), 30092-30106.

24.Wang, X.; Sun, X.; He, H.; Yang, H.; Lao, J.; Song, Y.; Xia, Y.; Xu, H.; Zhang, X.; Huang, F., A Two-Component Active Targeting Theranostic Agent Based on Graphene Quantum Dots. J. Mater. Chem. B 2015,3, 3583-3590.

25.He, H.; Wang, X.; Feng, Z.; Cheng, T.; Sun, X.; Sun, Y.; Xia, Y.; Wang, S.; Wang, J.; Zhang, X., Rapid Microwave-Assisted Synthesis of Ultra-Bright Fluorescent Carbon Dots for Live Cell Staining, Cell-Specific Targeting and in Vivo Imaging. J. Mater. Chem. B 2015,3 (24), 4786-4789.

26.Wang, X.; Sun, X.; Lao, J.; He, H.; Cheng, T.; Wang, M.; Wang, S.; Huang, F., Multifunctional Graphene Quantum Dots for Simultaneous Targeted Cellular Imaging and Drug Delivery. Colloids Surf., B 2014,122, 638-644.

27.He, H.; Sun, X.; Wang, X.; Sun, Y.; Xu, H.; Lu, J. R., Cyclic Arginyl-Glycyl-Aspartic Acid (Rgd) Peptide-Induced Synthesis of Uniform and Stable One-Dimensional Cdte Nanostructures in Aqueous Solution. RSC Adv. 2014,4 (23), 11794-11797.

28.Wang, X.; Boschetti, C.; Ruedas-Rama, M. J.; Tunnacliffe, A.; Hall, E. A. H., Ratiometric Ph-Dot Ansors. Analyst 2010,135 (7), 1585-1591.

29.Wang, X.; Ruedas-Rama, M. J.; Hall, E. A. H., The Emerging Use of Quantum Dots in Analysis. Anal. Lett. 2007,40 (8), 1497-1520.

30.Ruedas-Rama, M. J.; Wang, X.; Hall, E. A. H., A Multi-Ion Particle Sensor. Chem. Commun. 2007,  (15), 1544-1546.

31.Wang, X.; Nau, W. M., Kinetics of End-to-End Collision in Short Single-Stranded Nucleic Acids. J. Am. Chem. Soc. 2004,126 (3), 808-813.

32.Wang, X.; Bodunov, E. N.; Nau, W. M., Fluorescence Quenching Kinetics in Short Polymer Chains: Dependence on Chain Length. Optics and Spectroscopy 2003,95 (4), 560-570.

33.Zhang, X. Y.; Gramlich, G.; Wang, X.; Nau, W. M., A Joint Structural, Kinetic, and Thermodynamic Investigation of Substituent Effects on Host-Guest Complexation of Bicyclic Azoalkanes by Beta-Cyclodextrin. J. Am. Chem. Soc. 2002,124 (2), 254-263.

34.Nau, W. M.; Wang, X., Biomolecular and Supramolecular Kinetics in the Submicrosecond Time Range: The Fluorazophore Approach. ChemPhysChem 2002,3 (5), 393-398.

35.Wang, X.; Nau, W. M., Kinetics of One- and Two-Directional Charge Hopping in One-Dimensional Systems: Application to DNA. ChemPhysChem 2001,2 (12), 761-766.

 ◎发明专利

  1. 曲剑波,王晓娟,陈艳丽,宦关生,朱虎,一种聚苯乙烯材料表面亲水改性的方法,201310315379.0

  2. 王晓娟,黄方,王雅楠,曲剑波,何化,王生杰,一种KCK多肽修饰的金纳米簇及其制备方法, 201610387321.0

  3. 王晓娟,曲剑波,王雅楠,黄方,何化,王生杰,一种多肽修饰的金纳米簇及其制备方法, 201610389189.7

  4. 王晓娟,陈奇,张政媛,黄方,王生杰,潘思远,葛保胜,何化,一种以海藻为碳源的荧光碳量子点的制备方法和用途, 201611128316.4

  5. 王晓娟,马锡琦,王雅楠,黄方,葛保胜,何化,一种基因载体系统及其构建方法, 201711350421.7

  6. 王晓娟,陈奇,黄方,葛保胜,刘真真,一种以碳量子点为荧光指示剂的酚类抗氧化剂测定方法, 201711350390.5

  7. 王生杰,王晓娟,荆倩,曹美文,夏永清,一种石墨烯分散液的制备方法,201711379802.8

  8. 王晓娟,马锡琦,黄方,葛保胜,孙怡鑫,一种以金纳米簇为荧光指示剂检测肝素钠中糖类杂质的方法, 201711430491.3

 ◎指导研究生情况

学术学位硕士生招生方向:081700|化学工程与技术;专业学位硕士生招生方向:085600|材料与化工。指导硕士研究生多人荣获罗伯托罗卡奖学金以及国家奖学金;多位毕业生获得奖学金赴德国、香港、瑞士、澳大利亚进行科学研究及攻读博士学位;毕业生除继续攻读博士学位外,也在企业、教育、政府机关等各行业有所作为。






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